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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Eur J Immunol. 2017 Jan 27;47(3):516–526. doi: 10.1002/eji.201646343

Figure 1.

Figure 1

Rictor is required for iNKT-cell maturation. A. Frequency of iNKT-cells from WT and RictorcKO thymi was determined by flow cytometry. Gates were set on live, singlets, TCRβ+ CD1d-PBS57+ cells. Compiled frequency and absolute number of iNKT-cells is graphed. Data are from 12 independent experiments with 2–6 mice per experiment, n=24 mice per genotype, unpaired t-test mean ± S.D. B. Compiled frequency of Stage 0 iNKT (CD24+ iNKT) cells from 5 experiments with 2–4 mice per experiment, n=8 mice total per genotype. Frequencies of cells in Stages 1–3 (CD24−) are graphed using compiled data from 9 experiments with 2–6 mice per experiment, n=16 mice per genotype, multiple t-test mean ± S.D. Representative CD44 and NK1.1 profile of mature iNKT-cells from WT and RictorcKO mice is shown. * p ≤ 0.009.