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Pretreatment with mirtazapine decreased preference for the gambling-like lever by ~20%, switching preference to the FR lever. This switch suggests that the drug was able to attenuate preference for the lever associated with the large reinforcer. In the absence of mirtazapine (i.e., 24h post-injection), preference for the VR lever was restored. The range of the VR schedule was VR6–VR18. One-way repeated measures ANOVA with post hoc Newman-Keuls. **, p<0.01.
