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Coordinated carcinogenic effects of ARID1A/B. If ARID1A is mutated, the ARID1B mechanism enhances cancer development. ARID1B inhibition destabilizes the SWI/SNF complex, which leads to inhibition of cell proliferation. ARID1B, AT-rich interaction domain 1A; SWI/SNF, switch/sucrose non-fermentable complex.
