Fig. 3. Effect of ezetimibe on plasma relative cholesterol d₇ enrichment and percent endogenous cholesterol excretion.

Plasma relative cholesterol d₇ enrichment (A) is the cholesterol d₇ enrichment ratio during each metabolic measurement period. For post treatment, it is calculated as the ratio of net plasma cholesterol d₇ enrichment on day 57 (difference between day 57 and day 43) to that on day 44 (difference between day 44 and day 43). For pre-treatment, it is expressed as the cholesterol d₇ enrichment ratio of plasma cholesterol d₇ enrichment on day 15 to that on day 2. Percent cholesterol excretion (B) is expressed as percent fecal endogenous cholesterol excretion of the rapidly-mixing cholesterol pool. Treatment effects and the P values are shown above the bars of placebo (n=12) and ezetimibe (10 mg/day for 6 weeks, n=12).