Table 3.
Diagnostic test characteristics of PI-RADS v2 and 1H-MRSI for the identification of high grade prostate cancer (dominant Gleason pattern ≥ 4) and extraprostatic disease at radical prostatectomy.
| Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | |
|---|---|---|---|---|
| High grade prostate cancer (dominant Gleason pattern ≥ 4) | ||||
| Reader 1 | ||||
| Overall PI-RADS 2 | 92.9 (66.1-99.8) |
24.0 (9.4-45.1) |
40.6 (23.7-59.4) |
85.7 (42.1-99.6) |
| 1H MRSI | 85.7 (57.2-98.2) |
56.0 (34.9-75.6) |
52.2 (30.6-73.2) |
87.5 (61.7-98.4) |
| Reader 2 | ||||
| Overall PI-RADS 2 | 100.0 (76.8-100) |
24.0 (9.4-45.1) |
42.4 (25.5-60.8) |
100.0 (54.1-100) |
| 1H MRSI | 57.1 (28.9-82.3) |
68.0 (46.5-85.1) |
50.0 (24.7-75.3) |
73.9 (51.6-89.8) |
| Extraprostatic disease (stage ≥ T3a) | ||||
| Reader 1 | ||||
| Overall PI-RADS 2 | 20.0 (6.8-40.7) |
71.4 (41.9-91.6) |
55.6 (21.2-86.3) |
33.3 (17.3-52.8) |
| 1H MRSI | 64.0 (42.5-82.0) |
50.0 (23.0-77.0) |
69.6 (47.1-86.8) |
43.8 (19.8-70.1) |
| Reader 2 | ||||
| Overall PI-RADS 2 | 48.0 (27.8-68.7) |
64.3 (35.1-87.2) |
70.6 (44.0-89.7) |
40.9 (20.7-63.6) |
| 1H MRSI | 40.0 (21.1-61.3) |
57.1 (28.9-82.3) |
62.5 (35.4-84.8) |
34.8 (16.4-57.3) |
95% CI, 95% confidence interval.