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Regioselective Cys Chemical Editing
(A) Catalytic mechanism of protein tyrosine phosphatases.
(B) Cys-to-Dha conversion through a bisalkylation elimination reaction.
(C) Left: conversion of PtpA-Cys53 to Dha with reagent 1. Right: conversion of all Cys residues in PtpA to Dha by treatment with an excess of 1.
