Fig. 1.

Schematic representation of the different elements that compose our multi-scale model. We show the different levels of biological organisation as well as associated characteristic time scales [32], [17] associated to each of these layers: resource scale, i.e. oxygen which is supplied at a constant rate and consumed by the cell population, cellular scale, i.e. oxygen-regulated cell cycle progression which determines the age-dependent birth rate into the cellular layer, and, finally, the cellular scale, which is associated to the stochastic population dynamics.