Fig. 4. Panel A. This part represents the identical ROS production of a monomeric monometallic Cu–Aβ complex and of a monomeric hetero-bimetallic Cu,Zn–Aβ complex.52 Panel B. This part represents the ROS production by different Cu(ii) : Aβ ratios and by different states of aggregation of the peptide: fibrils produce less ROS than monomers, for the 0.5 : 1 ratio.52,78 Panel C. This last part compares the ROS production by amorphous aggregates of Cu(ii)–Aβ to the ROS production of aggregates in the presence of Zn(ii).69 Note that for all of the aggregation experiments, metal ions have been added at the beginning, i.e. these are metal-induced aggregations.
