Table 2.
Summary of cohort-specific and meta-analysis results for EWAS of continuous maternal pre-pregnancy BMI and newborn blood DNA methylation
| Cohort | N | Lambda (before adjusting for cells) | Bonferroni hits (before adjusting for cells) | Lambda (after adjusting for cells) | Bonferroni hits (after adjusting for cells) |
|---|---|---|---|---|---|
| ALSPAC | 788 | 1.53 | 12 | 1.18 | 1 |
| CBC (Hispanic) | 132 | 1.05 | 12 | 0.96 | 7 |
| CBC2 (White) | 155 | 1.80 | 31 | 1.19 | 3 |
| CHAMACOS | 368 | 1.34 | 1 | 0.87 | 0 |
| EARLI | 211 | 0.88 | 0 | 0.89 | 2 |
| GECKO | 176 | 1.75 | 14 | 1.15 | 2 |
| GEN3G | 170 | 1.13 | 10 | 1.04 | 10 |
| GENR | 875 | 1.86 | 248 | 1.96 | 11 |
| GOYA | 545 | 1.87 | 2 | 1.01 | 1 |
| IOW F2 | 53 | 1.08 | 0 | 1.05 | 0 |
| MEDALL (INMA+EDEN) | 330 | 1.24 | 0 | 0.92 | 0 |
| MoBa1 | 1034 | 4.69 | 39 | 2.74 | 1 |
| MoBa2 | 647 | 2.70 | 8 | 2.76 | 14 |
| MoBa3 | 231 | 1.03 | 0 | 0.78 | 1 |
| NEST | 384 | 0.76 | 0 | 0.93 | 0 |
| NFCS | 867 | 0.95 | 0 | 0.98 | 0 |
| NHBCS | 118 | 1.02 | 2 | 1.17 | 4 |
| RICHS | 96 | 1.89 | 14 | 2.92 | 33 |
| VIVA | 343 | 1.27 | 8 | 1.49 | 7 |
| FE Meta-analysis | 7523 | 3.27 | 9044 | 2.41 | 104 |
| RE Meta-analysis | 1825 | 25 |