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. 2017 Jul 21;26(20):4067–4085. doi: 10.1093/hmg/ddx290

Table 3.

Methylation sites where continuous maternal pre-pregnancy BMI was associated with offspring newborn blood methylation with a Bonferroni-corrected P-value <0.05 (P < 1.06 × 10−7) before and after adjustment for cell counts

Cell-unadjusted model
 Cell-adjusted model
CHR CpG site Gene βa SE P βa SE P
7 cg12009398 VIPR2 −1.31E-03 1.42E-04 2.49E-20 −1.01E-03 1.34E-04 5.88E-14
13 cg09285795 SOX1 −7.75E-04 1.10E-04 2.09E-12 −7.71E-04 1.12E-04 5.99E-12
2 cg23080818 RBMS1 −8.76E-04 1.08E-04 4.76E-16 −6.98E-04 1.04E-04 1.96E-11
12 cg25213362 TMPRSS12 −6.71E-04 8.91E-05 4.93E-14 −5.89E-04 8.82E-05 2.42E-11
10 cg17782974 TRIM8 1.29E-03 1.50E-04 7.18E-18 8.15E-04 1.25E-04 6.54E-11
7 cg05086444 VIPR2 −8.32E-04 1.30E-04 1.79E-10 −8.17E-04 1.25E-04 7.14E-11
1 cg03258665 EPHA2 −1.10E-03 1.12E-04 8.65E-23 −5.68E-04 8.78E-05 9.97E-11
12 cg20065216 DUSP16 −6.63E-04 9.88E-05 1.97E-11 −6.03E-04 9.32E-05 9.98E-11
11 cg26434090 DSCAML1 −7.94E-04 1.07E-04 1.10E-13 −6.97E-04 1.10E-04 2.27E-10
11 cg18268562 FOXR1 −6.27E-04 1.01E-04 4.72E-10 −6.51E-04 1.03E-04 2.36E-10
8 cg00285394 SQLE −8.68E-04 1.39E-04 4.57E-10 −8.96E-04 1.42E-04 2.66E-10
22 cg27179375 POM121L1P −1.33E-03 2.00E-04 2.85E-11 −1.07E-03 1.71E-04 3.65E-10
6 cg05586134 PTCRA −4.81E-04 6.32E-05 2.80E-14 −3.32E-04 5.33E-05 4.54E-10
3 cg07357021 PRICKLE2 −3.94E-04 5.08E-05 9.48E-15 −2.82E-04 4.59E-05 7.68E-10
1 cg21778193 MIR200B −1.09E-03 1.48E-04 1.42E-13 −8.75E-04 1.42E-04 7.86E-10
8 cg04836151 LY6H 9.72E-04 1.37E-04 1.27E-12 7.03E-04 1.15E-04 9.77E-10
17 cg09243648 SP6 −9.32E-04 1.25E-04 8.14E-14 −6.00E-04 9.85E-05 1.13E-09
15 cg07822775 PCSK6 −5.55E-04 6.98E-05 1.86E-15 −3.44E-04 5.65E-05 1.18E-09
10 cg14906690 KAT6B −8.09E-04 1.07E-04 3.76E-14 −7.06E-04 1.17E-04 1.47E-09
2 cg05309280 GORASP2 −5.62E-04 1.01E-04 2.63E-08 −6.07E-04 1.01E-04 1.58E-09
4 cg10635092 ZFYVE28 −7.89E-04 1.27E-04 5.12E-10 −7.11E-04 1.19E-04 2.30E-09
20 cg13403462 NECAB3 −1.37E-03 2.23E-04 9.21E-10 −1.38E-03 2.30E-04 2.36E-09
17 cg10187674 ABCA5 −2.98E-04 5.39E-05 3.05E-08 −3.21E-04 5.39E-05 2.47E-09
3 cg19762797 XXYLT1 −3.38E-04 4.32E-05 5.28E-15 −2.13E-04 3.58E-05 2.92E-09
1 cg09230763 MAP3K6 −9.16E-04 1.10E-04 8.18E-17 −6.04E-04 1.02E-04 3.09E-09
19 cg18156417 MAP2K2 −3.49E-04 5.11E-05 8.01E-12 −2.82E-04 4.77E-05 3.51E-09
7 cg26220185 MAD1L1 −6.65E-04 9.48E-05 2.23E-12 −4.06E-04 6.88E-05 3.68E-09
17 cg13540311 SEPT9 −3.33E-04 4.70E-05 1.40E-12 −2.46E-04 4.17E-05 3.92E-09
2 cg16877087 RBMS1 −5.85E-04 9.39E-05 4.72E-10 −5.62E-04 9.59E-05 4.66E-09
1 cg20594982 AGRN −1.20E-03 1.70E-04 1.57E-12 −9.95E-04 1.70E-04 5.17E-09
8 cg14660676 SQLE −1.09E-03 1.72E-04 2.36E-10 −1.05E-03 1.80E-04 5.21E-09
9 cg09723488 LHX6 −5.87E-04 7.14E-05 2.06E-16 −3.41E-04 5.84E-05 5.38E-09
8 cg13176454 ST3GAL1 −2.98E-04 3.77E-05 2.92E-15 −2.00E-04 3.43E-05 5.49E-09
8 cg14030674 ANK1 −1.08E-03 1.32E-04 3.01E-16 −5.50E-04 9.46E-05 5.97E-09
10 cg27102629 KAT6B −9.89E-04 1.24E-04 1.90E-15 −6.68E-04 1.16E-04 7.37E-09
2 cg06399427 RBMS1 −5.17E-04 8.11E-05 1.88E-10 −4.76E-04 8.23E-05 7.39E-09
16 cg01979489 PDIA2 −4.74E-04 6.71E-05 1.57E-12 −3.24E-04 5.63E-05 8.54E-09
7 cg05837990 CDHR3 −1.44E-03 2.39E-04 1.83E-09 −1.40E-03 2.43E-04 9.12E-09
9 cg21241902 NSMF −6.10E-04 8.93E-05 8.16E-12 −4.87E-04 8.49E-05 9.88E-09
8 cg00729699 DMTN −7.83E-04 1.15E-04 1.16E-11 −5.52E-04 9.64E-05 1.03E-08
20 cg03719642 UCKL1 −6.86E-04 1.18E-04 5.46E-09 −6.83E-04 1.19E-04 1.07E-08
8 cg18144647 SFRP1 −5.55E-04 9.28E-05 2.14E-09 −5.22E-04 9.13E-05 1.11E-08
12 cg21814615 KNTC1 −4.62E-04 7.19E-05 1.34E-10 −3.64E-04 6.41E-05 1.43E-08
1 cg14528056 GBAP1 6.87E-04 1.14E-04 1.75E-09 5.14E-04 9.08E-05 1.45E-08
1 cg22820188 LMNA −7.08E-04 8.59E-05 1.69E-16 −4.38E-04 7.74E-05 1.56E-08
14 cg08289937 DDHD1 −3.54E-04 4.74E-05 7.43E-14 −2.51E-04 4.44E-05 1.56E-08
9 cg21186778 RCL1 −7.09E-04 9.24E-05 1.67E-14 −3.63E-04 6.43E-05 1.58E-08
5 cg17514558 PCDHB19P −6.14E-04 1.09E-04 1.69E-08 −6.46E-04 1.14E-04 1.67E-08
8 cg15240102 LOC286083 −7.30E-04 9.23E-05 2.74E-15 −4.00E-04 7.10E-05 1.80E-08
18 cg21026022 CABYR −1.21E-03 1.75E-04 5.52E-12 −9.95E-04 1.77E-04 1.87E-08
13 cg18995031 RASA3 −4.11E-04 5.70E-05 5.85E-13 −2.84E-04 5.09E-05 2.31E-08
22 cg04027757 POM121L1P −7.26E-04 1.27E-04 9.59E-09 −6.45E-04 1.15E-04 2.33E-08
6 cg01963618 LINC01622 −4.79E-04 6.77E-05 1.39E-12 −3.51E-04 6.29E-05 2.40E-08
20 cg21445553 GGTLC1 −1.09E-03 1.87E-04 5.90E-09 −9.50E-04 1.70E-04 2.41E-08
16 cg05976575 CMTM2 −4.72E-04 6.35E-05 1.15E-13 −3.21E-04 5.75E-05 2.49E-08
2 cg13758186 CREG2 −4.86E-04 7.71E-05 2.90E-10 −3.89E-04 6.98E-05 2.52E-08
2 cg20710902 BUB1 −3.44E-04 5.63E-05 1.04E-09 −2.74E-04 4.94E-05 2.88E-08
6 cg03046925 GPX6 −4.25E-04 6.26E-05 1.06E-11 −2.80E-04 5.05E-05 2.98E-08
10 cg18330571 EBF3 −4.92E-04 7.14E-05 5.75E-12 −3.68E-04 6.65E-05 3.15E-08
3 cg11156132 PRKCD −6.83E-04 9.30E-05 1.97E-13 −3.21E-04 5.82E-05 3.36E-08
2 cg18499001 LOC388942 −2.04E-04 3.75E-05 4.98E-08 −2.12E-04 3.85E-05 3.72E-08
2 cg05113927 UCN −6.23E-04 1.11E-04 1.83E-08 −6.10E-04 1.11E-04 3.85E-08
4 cg22670329 CXCL6 −4.29E-04 7.97E-05 7.32E-08 −4.16E-04 7.56E-05 3.86E-08
2 cg15913725 TSSC1 −2.76E-04 4.46E-05 5.89E-10 −2.37E-04 4.32E-05 4.46E-08
7 cg01881287 EFCAB10 −8.12E-04 1.29E-04 3.40E-10 −7.22E-04 1.32E-04 4.84E-08
16 cg05635274 PRSS21 −5.84E-04 9.30E-05 3.24E-10 −4.82E-04 8.84E-05 4.95E-08
16 cg03221837 IRX3 −5.48E-04 7.77E-05 1.73E-12 −4.22E-04 7.76E-05 5.20E-08
13 cg13557773 RASA3 −9.98E-04 1.74E-04 9.82E-09 −9.53E-04 1.75E-04 5.42E-08
8 cg14434213 RNF5P1 −8.52E-04 1.42E-04 2.21E-09 −7.83E-04 1.45E-04 6.04E-08
6 cg05659486 LRRC1 −6.47E-04 8.98E-05 5.82E-13 −4.10E-04 7.58E-05 6.22E-08
5 cg15029475 C5orf38 −7.23E-04 1.01E-04 7.55E-13 −4.88E-04 9.01E-05 6.32E-08
19 cg22545168 LAIR1 −4.79E-04 6.92E-05 4.62E-12 −3.49E-04 6.45E-05 6.32E-08
5 cg23111106 OSMR −4.73E-04 6.81E-05 3.77E-12 −3.16E-04 5.85E-05 6.34E-08
7 cg23749005 PTPRN2 −1.00E-03 1.66E-04 1.36E-09 −8.95E-04 1.65E-04 6.34E-08
17 cg21937867 PRCD −4.63E-04 6.56E-05 1.70E-12 −2.88E-04 5.33E-05 6.39E-08
1 cg04972348 MIR200B −1.30E-03 1.65E-04 3.23E-15 −8.61E-04 1.59E-04 6.66E-08
14 cg05881436 SNAPC1 −3.59E-04 5.77E-05 4.93E-10 −2.78E-04 5.16E-05 6.84E-08
3 cg23166970 MCCC1 −1.32E-04 2.42E-05 4.87E-08 −1.29E-04 2.39E-05 7.66E-08
5 cg08407524 LINC01023 −3.49E-04 5.16E-05 1.27E-11 −2.33E-04 4.34E-05 8.28E-08
14 cg01428678 GPHN −1.89E-04 3.38E-05 2.19E-08 −1.85E-04 3.45E-05 8.69E-08
19 cg26284544 TGFBR3L −8.41E-04 1.44E-04 5.39E-09 −7.64E-04 1.43E-04 8.79E-08
3 cg12155036 LINC00887 −6.84E-04 1.22E-04 2.04E-08 −6.49E-04 1.21E-04 9.00E-08
22 cg25432807 POM121L1P −6.07E-04 1.10E-04 3.08E-08 −5.35E-04 1.00E-04 9.32E-08
6 cg25521481 TTBK1 −7.08E-04 1.01E-04 2.53E-12 −5.34E-04 1.00E-04 9.78E-08
3 cg25185429 ITPR1 −3.02E-04 3.96E-05 2.44E-14 −1.79E-04 3.37E-05 1.02E-07
2 cg01517690 ZSWIM2 −6.24E-04 1.08E-04 7.55E-09 −5.52E-04 1.04E-04 1.02E-07
a

Difference in newborn DNA methylation beta value per 1 kg/m2 increase in maternal pre-pregnancy BMI.