Table 4.
Risk of aseptic meningitis following mumps-containing vaccination and risk of immune thrombocytopenic purpura (ITP) following measles-containing vaccination; overall and by vaccine strain
| SCRI analyses | |||||
|---|---|---|---|---|---|
| Mumps vaccine strain1 | Eligible confirmed aseptic meningitis cases2 | Follow-up (days) | Relative incidence (IRR) | ||
| Event in risk period (8-35 days) | Event in non-risk period (43-84 days) | Median (P25-P75) | Unadjusted (95% CI) | Adjusted 95% CI | |
| Overall | 35 | 5 | 85 (85, 85) | 10.9 (4.2- 27.8) | 10.8 (4.0-29.2) |
| Overall3 | 22 | 3 | 85 (85, 85) | 11.7 (3.5-39.3) | 12.4 (3.1-49.1) |
| Hoshino/Leningrad-Zagreb/UrabeAm9 | 27 | 2 | 85 (85, 85) | 20.3 (4.8-85.2) | Non-estimable |
| Hoshino/Leningrad-Zagreb/UrabeAm9* | 14 | 0 | 85 (85, 85) | Non-estimable | Non-estimable |
| Leningrad-Zagreb | 7 | 1 | 85 (85, 85) | 10.8 (1.3-87.4) | 6.4 (0.3-124.4) |
| RIT 4385/Jeryl Lynn (Level B) | 0 | 1 | 85 (85, 85) | Non-estimable | Non-estimable |
| Measles vaccine strain | Eligible confirmed ITP cases1 | Follow-up (days) | Relative incidence (IRR) | ||
| Event in risk period (8-35 days) | Event in non-risk period (43-84 days) | Median (P25-P75) | Unadjusted 95% CI | Adjusted 95% CI | |
| Overall | 36 | 12 | 85 (70, 85) | 5.0 (2.5-9.7) | 5.6 (2.7-11.9) |
| Overall3 | 36 | 8 | 85 (70, 85) | 7.7 (3.5-17.3) | 9.1 (3.7-22.3) |
| AIK-C/ Edmonston-Zagreb /Schwarz | 2 | 5 | 85 (85, 85) | 0.51 (0.10-2.54) | 0.54 (0.08-3.55) |
| Edmonston-Zagreb | 7 | 1 | 85 (67, 85) | 11.1 (1.4-90.3) | 8.4 (0.7-100.3) |
| Enders´ Edmonston | 11 | 3 | 85 (43, 85) | 8.5 (1.9-38.1) | 28.7 (1.9-443.5) |
| Schwarz | 14 | 1 | 85 (76, 85) | 20.7 (2.7-157.6) | Non-estimable |
| Shanghai-191 | 0 | 1 | 85 (85, 85) | Non-estimable | Non-estimable |
1
There were no cases within days 8-35 or days 43-84 following first dose vaccination with mumps strains S79 or Urabe Am9.
2
The remaining cases occurred during the washout periods (days 1-7, days 36-42 following vaccination)
3
Excluding cases from Iran-01 since this site did not provide exact vaccination dates