Table 1.
Baseline characteristics and angiographic data categorized based on METs achieved
| Variable | Exercise Work Load (N = 1,052)
|
P value between MET categories | ||||||
|---|---|---|---|---|---|---|---|---|
| <7 METs (N=464)
|
P value | ≥7 METs (N=588)
|
P value | |||||
| PCI+OMT (N=241) |
OMT (N=223) |
PCI+OMT (N=286) |
OMT (N=302) |
|||||
| Age (years) mean ± SD | 64 ± 9 | 65 ± 9 | 0.30 | 59 ± 9 | 58 ± 9 | 0.23 | <0.001* | |
| Men | 187 (78%) | 173 (78%) | 1.00 | 258 (90%) | 281 (93%) | 0.21 | <0.001* | |
| White | 209 (87%) | 196 (88%) | 0.78 | 262 (92%) | 256 (86%) | 0.03 | 0.67 | |
| BMI mean ± SD (kg/m2) | 30 ± 5 | 29 ± 5 | 0.13 | 29 ± 4 | 29 ± 5 | 0.75 | 0.11 | |
| Never smoked | 48 (20%) | 52 (23%) | 0.37 | 54 (19%) | 74 (25%) | 0.10 | 0.93 | |
| Hypertension | 152 (63%) | 136 (62%) | 0.74 | 164 (59%) | 172 (58%) | 0.84 | 0.14 | |
| Diabetes mellitus | 72 (30%) | 60 (27%) | 0.50 | 66 (23%) | 85 (29%) | 0.15 | 0.34 | |
| Family history of CAD | 106 (48%) | 88 (44%) | 0.36 | 153 (58%) | 157 (56%) | 0.65 | <0.001* | |
| Myocardial infarction | 68 (29%) | 76 (35%) | 0.17 | 97 (34%) | 96 (32%) | 0.64 | 0.54 | |
| CABG | 17 (7%) | 21 (9%) | 0.35 | 27 (9%) | 19 (6%) | 0.16 | 0.83 | |
| PCI | 35 (15%) | 19 (9%) | 0.04 | 40 (14%) | 44 (15%) | 0.85 | 0.21 | |
| Angina pectoris | 217 (90%) | 200 (90%) | 0.79 | 241 (85%) | 256 (85%) | 0.94 | 0.01* | |
| CCS Angina Class | 0 | 23 (10%) | 23 (10%) | 0.46 | 44(15%) | 46 (15%) | 0.12 | <0.001* |
| 1 | 57 (24%) | 58 (26%) | 89 (31%) | 104 (34%) | ||||
| 2 | 94 (39%) | 95(43%) | 106(37%) | 123 (41%) | ||||
| 3 | 66 (28%) | 47 (21%) | 46 (16%) | 29 (10%) | ||||
| PAD | 17 (7%) | 10 (5%) | 0.25 | 9 (3%) | 13 (4%) | 0.46 | 0.11 | |
| Heart failure | 6 (3%) | 6 (3%) | 0.88 | 14 (5%) | 7 (2%) | 0.09 | 0.36 | |
| Stroke/TIA | 15 (6%) | 15 (7%) | 0.84 | 13 (5%) | 20 (7%) | 0.28 | 0.55 | |
| Renal disease | 5 (2%) | 0 | 0.03 | 6 (2%) | 7 (2%) | 0.86 | 0.16 | |
| Heart rate (bpm) mean ± SD | 64 ± 10 | 66 ± 13 | 0.08 | 64 ±11 | 65 ± 11 | 0.39 | 0.64 | |
| SBP (mm Hg) mean ± SD | 135 ± 21 | 134 ± 18 | 0.71 | 131 ± 18 | 130 ± 18 | 0.50 | 0.002* | |
| DBP (mm Hg) mean ± SD | 64 ± 11 | 73 ± 11 | 0.83 | 76 ± 11 | 76 ± 11 | 0.99 | <0.001* | |
| Number of arteries narrowed | 1 | 80 (33%) | 65 (29%) | 0.28 | 105 (37%) | 99 (33) | 0.61 | 0.49 |
| 2 | 100 (41%) | 87 (39%) | 105 (37%) | 118 (39%) | ||||
| 3 | 61 (25%) | 71 (32%) | 76 (27%) | 85 (28%) | ||||
| Ejection Fraction | 63 ± 11% | 63 ± 10% | 0.55 | 63 ± 11% | 62 ± 9% | 0.54 | 0.28 | |
| Medications (n) | 206 | 183 | 233 | 247 | ||||
| Aspirin | 185 (90%) | 167 (91%) | 0.63 | 202 (87%) | 216 (87%) | 0.81 | 0.12 | |
| ACEi/ARB | 101 (49%) | 89 (49%) | 0.98 | 115 (49%) | 123 (50%) | 0.85 | 0.89 | |
| Beta-blocker | 155 (75%) | 129 (71%) | 0.33 | 165(70%) | 176 (71%) | 0.80 | 0.44 | |
| Calcium channel blocker | 72 (35%) | 60 (33%) | 0.68 | 59 (25%) | 61 (25%) | 0.92 | 0.003* | |
ACEi = angiotensin converting enzyme inhibitor; ARB = angiotensin receptor blocker; BMI = body mass index; CAD = coronary artery disease; CABG = coronary artery bypass grafting; CCS = Canadian Cardiovascular Class; DBP = diastolic blood pressure; METs = metabolic equivalents; OMT = optimal medical therapy; PAD = peripheral arterial disease; PCI = percutaneous coronary intervention; SBP = systolic blood pressure; SD = standard deviation; TIA = transient ischemic attack.
*
p <0.01 significant.