Figure 5.

The structural similarities and differences of hPOT1 and spPot1 A) Crystal structures of hPOT1 OB1 (IXJV)⁷³ overlaid with Pot1pN (1QZH)⁷² $\text{OB}1$ is shown in magenta and $\text{Pot}1\text{pN}$ is shown in blue. The 6mer ligand bound by OB1 $(\text{OB}1\text{-DNA})$ is shown in yellow and the 6mer ligand bound by Pot1pN $(\text{Pot}1\text{pN-}6\text{mer})$ is shown in cyan. B) Crystal structures of hPOT1 OB2 (IXJV)⁷³ overlaid with Pot1pC (4HIK).⁷⁴ $\text{OB}2$ is shown in light brown and $\text{Pot}1\text{pC}$ is shown in green. The 4mer ligand bound by OB2 $(\text{OB}2\text{-DNA})$ is shown in orange and the 9mer ligand bound by Pot1pC $(\text{Pot}1\text{pC-}9\text{mer})$ is shown in purple.