Osteocyte (white stellate cell), sense mechanical forces through cellular sensors (integrins, cilium, calcium channels and GPCR) and then transform these biomechanical stimuli into biological responses that results in the secretion of several factors capable of affecting effector cells such as osteoblasts (dark blue), bone lining cells (light blue) and osteoclasts (pink). Osteocytes, osteoblast and bone lining cells express PTHRs (black) and LRP5/4 (blue) which are involved in mechanobiology