Table 2.
Adverse events, % |
nab-Paclitaxel plus carboplatin (n = 61) |
Gemcitabine plus carboplatin (n = 132) |
P-value |
---|---|---|---|
Hematologic | |||
Anemia | 62 | 66 | 0.63 |
Grade 3/4 | 10 | 26 | 0.01 |
Neutropenia | 51 | 56 | 0.54 |
Grade 3/4 | 2 | 11 | 0.04 |
Thrombocytopeniaa | 16 | 23 | 0.34 |
Non-hematologic (grade not specified) | |||
Nausea | 89 | 73 | 0.01 |
Pain | 79 | 79 | 0.99 |
Vomiting | 61 | 58 | 0.69 |
Fatigue | 62 | 63 | 0.94 |
Diarrhea | 59 | 48 | 0.15 |
Mucositis | 25 | 31 | 0.36 |
Neuropathy | 30 | 12 | < 0.01 |
Dehydration | 25 | 17 | 0.20 |
Note:
Not able to calculate grade 3 and 4 thrombocytopenia due to low incidence and/or missing lab values.