Table 6.

Ora Calibra Ocular Discomfort and 4-Symptom Questionnaire

	Rohto Dry-Aid	Systane Ultra	Ocular Discomfort	Burning	Dryness	Grittiness	Stinging
Visit 1 pre-dosing	Rohto		2.95	1.64	3.21	1.67	1.18
		Systane	2.83	1.49	2.90	2.05	1.24
	p-value		0.478	0.593	0.114	0.197	0.815
Visit 1 5 Min Post-Dose	Rohto		1.74	0.90	1.54	0.59	0.82
		Systane	1.68	0.80	1.68	1.27	1.05
	p-value		0.815	0.698	0.599	0.012	0.374
Visit 2	Rohto		2.23	1.31	2.26	1.15	0.85
		Systane	2.17	1.17	2.20	1.63	0.85
	p-value		0.772	0.594	0.790	0.062	0.972
Visit 3	Rohto		1.97	0.97	2.15	1.36	0.79
		Systane	2.15	1.22	2.29	1.59	0.85
	p-value		0.420	0.341	0.519	0.386	0.802

Notes: Subjects rated the severity of each of the following symptoms with regards to how both their eyes felt, in general: overall ocular discomfort, burning, dryness, grittiness, and stinging, according to a 6-point (0–5) scale, where 0= none and 5= worst. Scores were collected before and after dosing at Visit 1 and at Visits 2 and 3. Both agents reduced mean discomfort scores postdosing at Visit 1; the decrease in mean grittiness score in the Rohto group was significantly greater than that seen in the Systane group. p-values in bold indicate significance (p<0.05).