Table 3.
Change in CVD Risk Factors from Baseline to Two Years by Percent Weight Change
| Means (Standard Errors) By Percent Weight Loss Categories | |||||||
|---|---|---|---|---|---|---|---|
| Lost ≥ 5% | Lost < 5% – Lost > 1% |
Lost ≤ 1% – Gain ≤ 1% |
Gain >1% – Gain <5% |
Gain ≥ 5% | Nominal P-Value |
Adjusted P- Value |
|
| Weight change (kg) | −6.98 (0.19) | −2.1 (0.17) | −0.04 (0.24) | 1.96 (0.19) | 6.35 (0.23) | <0.0001 | -- |
| Percent of Weight | −9.52 (0.24) | −2.97 (0.21) | −0.04 (0.31) | 2.77 (0.24) | 8.93 (0.29) | <0.0001 | -- |
| Cholesterol (mg/dl) | −4.42 (2.16) | 0.54 (1.91) | −0.26 (2.78) | 1.16 (2.12) | 6.87 (2.61) | 0.03 | 0.27 |
| HDL (mg/dL) | 4.21 (1.02) | 2.44 (0.9) | −0.53 (1.31) | −0.84 (1) | −1.24 (1.23) | 0.0007 | 0.0063 |
| LDL (mg/dL) | −4.66 (1.79) | 0.14 (1.59) | 1.41 (2.31) | 1.79 (1.76) | 5.78 (2.17) | 0.006 | 0.054 |
| Triglycerides (mg/dL) | −20.01 (4.60) | −10.26 (4.07) | −5.76 (5.91) | 1.21 (4.52) | 11.92 (5.55) | 0.0002 | 0.0018 |
| Glucose (mg/dL) | −0.99 (0.60) | 0.12 (0.53) | 0.93 (0.77) | 1.77 (0.60) | 1.56 (0.73) | 0.01 | 0.09 |
| Insulin (uU/mL) | −2.62 (0.39) | −1.25 (0.34) | −0.53 (0.5) | 0.15 (0.39) | 0.8 (0.47) | <0.0001 | 0.0009 |
| HOMA-IR ((mg/dL)*(uU/mL)) | −0.61 (0.09) | −0.28 (0.08) | −0.08 (0.12) | 0.07 (0.09) | 0.22 (0.11) | <0.0001 | 0.0009 |
| SBP (mmHg) | −4.34 (0.85) | −3.45 (0.76) | −4.04 (1.08) | −1.41 (0.85) | 0.31 (1.02) | 0.002 | 0.018 |
| DBP (mmHg) | −2.01 (0.64) | −2.05 (0.57) | −1.86 (0.81) | −0.35 (0.64) | 0.27 (0.77) | 0.05 | 0.45 |
Model adjusted for Percent Weight Change Baseline to Year 2, Treatment Arm, and Clinic. Interaction of Percent Weight Change and Treatment Arm was not significant in any of these analyses. With 9 CVD risk factors and Bonferroni adjustment for multiple comparisons, a p-value of p<0.0045 is needed; bold font signifies that the differences among the five weight loss categories are statistically significant after adjustment.