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. 2017 Oct 23;4(6):e403. doi: 10.1212/NXI.0000000000000403

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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B cells are assessed as CD3⁻CD14⁻CD19⁺ of which subpopulations are identified as B memory (B mem CD24⁺CD38⁻), B mature (B mat CD24⁺CD38^low), and B regulatory (B reg CD24⁺CD38^high). (A) A clear trend in reduction of B-cell number and percentage was observed in 3 patients treated for 3 months. (B) B-cell percentage (upper panel) and numbers (lower panel) were reduced after 1 year of treatment with teriflunomide. Data are presented as mean ± SEM for 7 treated patients with MS. *p < 0.05. (C) While the proportions of the different B-cell subpopulations did not change after 12 months of treatment (upper panel), numbers of B mat and B reg cells were decreased (*p < 0.05), and B mem cell numbers showed a clear trend to decrease (lower panel). Data are presented as mean ± SEM for 7 treated patients with MS.