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. 2017 Oct;58(12):5485–5496. doi: 10.1167/iovs.17-22399

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Copyright 2017 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Decreased number of retinal ganglion cells in CASK^(+/−) mice. (A) Immunostaining of retina with antibodies against calretinin reveals normal lamination in CASK^(+/−) mutants at P26. (B) Representative images of retinas stained with DAPI and RBPMS (a marker of RGCs) reveal a significant loss of cells in the ganglion cell layer in CASK^(+/−) mutants compared with controls. Scale bar: 25 μm. Lower panel is a grayscale image for better visualization. (C) Quantition of cells in the ganglion cell layer in indicated staining. (*P < 0.05). Data are relative to wild-type levels and is plotted as mean ± SEM, n = 4.