Figure 1. Prolonged home actigraphy monitoring.

(A) From the sixth day administration of 7 mg of melatonin was discontinued and the major sleep (ie, inactivity) period progressively shifted forward. (B) Treatment with 7 mg of melatonin determined a partial alignment of the major sleep period, with persistent sleep onset insomnia and tendency to sleep in the early morning. (C) Restoration of wake-sleep rhythm coupled with the day/night cycle after treatment with 14 mg of melatonin.