Table 1.
Baseline characteristics of 456 survivors and non-survivors with moderate and severe ARDS
| Variables | All patients | Survivors N = 275 |
Non-survivors N = 181 |
P value |
|---|---|---|---|---|
| Age, years | 62 (51–72) | 60 (48–70) | 63 (55–72) | 0.008 |
| Female | 113 (41.1) | 59 (32.6) | 0.075 | |
| Weight, kg | 80 (70–90) | 80 (70–90) | 80 (68–87) | 0.347 |
| APACHE IV | 68 (51–89) | 72 (58–95) | 90 (74–113) | < 0.001 |
| Charlson comorbidity index 2 | 1 (0–3) | 1 (0–2) | 1 (0–3) | 0.103 |
| Lung Injury Prediction Score | 8.5 (7–10) | 8 (6.5–10) | 9 (7–10) | 0.074 |
| Tidal volume, ml/kg | 6.3 (5.3–7.6) | 6.3 (5.3–7.8) | 6.3 (5.4–7.3) | 0.412 |
| Respiratory rate | 23 (17–29) | 20 (16–27) | 25 (19–30) | 0.001 |
| PEEP, cmH2O | 10 (8–12) | 10 (8–12) | 10 (8–13) | 0.436 |
| FiO2, % | 60 (50–75) | 60 (50–70) | 60 (50–80) | 0.462 |
| Arterial pH | 7.34 (7.26–7.41) | 7.35 (7.28–7.41) | 7.31 (7.22–7.39) | 0.001 |
| PaCO2, kPa | 5.8 (5.1–6.9) | 5.7 (5–6.9) | 6 (5.2–7.3) | 0.072 |
| PaO2/FiO2 | 120 (89–149) | 123 (91–149) | 115 (89–149) | 0.353 |
| SpO2/FiO2 | 160 (126–190) | 163 (127–191) | 157 (124–190) | 0.344 |
| Vasopressor use in first 24 h | 293 (64.3) | 164 (59.6) | 129 (71.3) | 0.015 |
| ARDS class | ||||
| Moderate ARDS | 300 (65.8) | 181 (65.8) | 119 (65.7) | 1 |
| Severe ARDS | 156 (34.2) | 94 (34.2) | 62 (34.3) | 1 |
| Cause of ARDS | ||||
| Pulmonary origin | 325 (71.3) | 200 (72.7) | 125 (69.1) | 0.732 |
| Non-pulmonary origin | 185 (40.6) | 104 (37.8) | 81 (44.8) | 0.382 |
Categorical variables: number (percentage); continuous variables: median (25–75 percentile)
PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen, PaCO 2 arterial carbon dioxide tension, PaO 2 arterial oxygen tension, SpO 2 pulse oximetry saturation, ARDS acute respiratory distress syndrome, APACHE IV acute physiology and chronic evaluation IV