. Author manuscript; available in PMC: 2018 Nov 15.

Published in final edited form as: Eur J Pharm Sci. 2017 Jul 31;109:182–190. doi: 10.1016/j.ejps.2017.07.034

Table 4.

Effects of trapping agents on the inactivation of CYP3A4 by licochalcone A.

Assay components		% Control activity^a

Human liver microsomes	Licochalcone A	100
	Licochalcone A, NADPH	49.5
	Licochalcone A, NADPH, glutathione	38.5
	Licochalcone A, NADPH, superoxide dismutase	46.9
	Licochalcone A, NADPH, catalase	42.4

Recombinant human CYP3A4	Licochalcone A	100
	Licochalcone A, NADPH	42.0
	Licochalcone A, NADPH, glutathione	32.4
	Licochalcone A, NADPH, superoxide dismutase	28.1
	Licochalcone A, NADPH, catalase	38.8

mean of two experiments