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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Adv Healthc Mater. 2017 Jul 21;6(20):10.1002/adhm.201700313. doi: 10.1002/adhm.201700313

Figure 2.

Figure 2

Formulation and characterization of GW-encapsulated NPs. (A) Schematic of Col IV-GW-NP design. The lipids/polymer/drug mixture were dissolved in benzyl alcohol/ethyl acetate co-solvent (2:8, v/v), and the NPs were formed by modified single-emulsion method in water via a single self-assembly process. (B) The mean hydrodynamic diameters of empty NPs, GW-NPs, and Col IV-GW-NPs in PBS and serum (100% FBS), respectively, determined by DLS. (C) Representative TEM images of Col IV-GW-NPs. The scale bars of the left image and the right high-magnification image are 100 nm and 20 nm, respectively. (D) In vitro drug release profiles of GW-NPs and Col IV-GW-NPs incubated at 100 rpm and 37 °C in PBS.