Table 1.
Summary of histopathological evaluation of kidneys in young or aged WT and Cyp2e1-null mice.
| Wild type young | Wild type old | Cyp2e1-null young | Cyp2e1-null old | |
|---|---|---|---|---|
| Number of animals examined | 7 | 7 | 7 | 7 |
| Glomerulonephropathy | 0 | 7 | 0 | 4 |
| Slight | 5 | 4 | ||
| Moderate | 2 | |||
| Inflammatory cell foci | 1 | 7 | 1 | 4 |
| Slight | 1 | 2 | 1 | 1 |
| Moderate | 2 | 2 | ||
| Severe | 3 | 1 | ||
| Tubular cytoplasmic vacuolation | 0 | 4 | 0 | 2 |
| Slight | 4 | 2 | ||
| Tubular degeneration/regeneration | 0 | 6 | 0 | 2 |
| Slight | 4 | 1 | ||
| Moderate | 2 | 1 | ||
| Fibrosis | 0 | 5 | 0 | 2 |
| Slight | 2 | 1 | ||
| Moderate | 2 | 1 | ||
| Severe | 1 |
Grading System: slight, few glomeruli or tubules or surrounding cells affected; moderate, multiple glomeruli or tubules or surrounding cells affected; severe, diffuse tissue infiltration and/or damage.