Figure 5.

Examples of microfluidic approaches for exosome detection. (A) RInSE system leverages inertial focusing to perform continuous bead-based isolation and fluorescence analysis via flow cytometry. Reprinted from Ref. [77], with the permission of AIP Publishing. (B) Enhanced immunocapture via electrohydrodynamic nanoshearing using on-chip electrodes enables colorimetric detection of exosomes. Adapted with permission from Ref. [73]. Copyright 2014 American Chemical Society. (C) μNMR-based detection using on-chip microcoil arrays is achieved by immunoafinity labeling using magnetic nanoparticles. Adapted by permission from Macmillan Publishers Ltd: Nature Medicine Ref. [108], copyright 2012. (D) An aptamer-based electrochemical approach enables label-free detection. Reprinted from Ref. [82], Copyright 2016, with permission from Elsevier.