Table 3.
Genes showing > 1.2-fold differential change over time in vilazodone vs. paroxetine.
| Change in RNA expression (T2-T1 log2 RNA) | |||||
|---|---|---|---|---|---|
| Paroxetine | Vilazodone | Fold- difference | |||
| Up-regulated > 1.2-fold | |||||
| LCN2 | − 0.158 | 0.406 | 1.48 | ||
| CAMP | 0.004 | 0.536 | 1.45 | ||
| LOC653600 | 0.046 | 0.535 | 1.40 | ||
| PGLYRP1 | − 0.045 | 0.372 | 1.33 | ||
| CEACAM8 | − 0.099 | 0.300 | 1.32 | ||
| LTF | − 0.004 | 0.371 | 1.30 | ||
| DEFA4 | 0.055 | 0.408 | 1.28 | ||
| SH3BGRL2 | − 0.160 | 0.193 | 1.28 | ||
| MGC13057 | − 0.128 | 0.216 | 1.27 | ||
| GP9 | − 0.084 | 0.247 | 1.26 | ||
| RNASE3 | 0.003 | 0.333 | 1.26 | ||
| TMEM158 | − 0.080 | 0.249 | 1.26 | ||
| CD24 | − 0.082 | 0.243 | 1.25 | ||
| LOC645128 | − 0.061 | 0.260 | 1.25 | ||
| CLEC1B | − 0.155 | 0.166 | 1.25 | ||
| CEACAM6 | − 0.047 | 0.273 | 1.25 | ||
| PF4V1 | − 0.018 | 0.303 | 1.25 | ||
| HSPA1B | − 0.036 | 0.277 | 1.24 | ||
| MPL | − 0.060 | 0.249 | 1.24 | ||
| SPARC | − 0.125 | 0.183 | 1.24 | ||
| TREML1 | 0.009 | 0.308 | 1.23 | ||
| SDPR | − 0.192 | 0.103 | 1.23 | ||
| OLFM4 | − 0.064 | 0.226 | 1.22 | ||
| ALOX12 | − 0.117 | 0.172 | 1.22 | ||
| TSC22D1 | − 0.060 | 0.227 | 1.22 | ||
| NGFRAP1 | − 0.027 | 0.258 | 1.22 | ||
| ITGA2B | − 0.125 | 0.157 | 1.22 | ||
| GPR18 | − 0.059 | 0.221 | 1.21 | ||
| ID3 | − 0.063 | 0.217 | 1.21 | ||
| NRGN | − 0.152 | 0.128 | 1.21 | ||
| MMD | − 0.108 | 0.166 | 1.21 | ||
| TUBB1 | − 0.208 | 0.064 | 1.21 | ||
| CA2 | − 0.158 | 0.111 | 1.21 | ||
| HIST1H2BJ | 0.080 | 0.347 | 1.20 | ||
| ACRBP | − 0.056 | 0.210 | 1.20 | ||
| Down-regulated > 1.2-fold | |||||
| IL8 | 0.533 | − 0.584 | 0.46 | ||
| EGR1 | 0.681 | − 0.380 | 0.48 | ||
| CCL3 | 0.500 | − 0.393 | 0.54 | ||
| FOSB | 0.472 | − 0.383 | 0.55 | ||
| IL1B | 0.613 | − 0.236 | 0.56 | ||
| CCL3L1 | 0.472 | − 0.326 | 0.57 | ||
| EGR2 | 0.407 | − 0.355 | 0.59 | ||
| CCL3L3 | 0.254 | − 0.456 | 0.61 | ||
| JUN | 0.369 | − 0.340 | 0.61 | ||
| OSM | 0.381 | − 0.295 | 0.63 | ||
| TNF | 0.408 | − 0.266 | 0.63 | ||
| PTGS2 | 0.302 | − 0.333 | 0.64 | ||
| RGS1 | 0.345 | − 0.251 | 0.66 | ||
| JUNB | 0.277 | − 0.279 | 0.68 | ||
| DUSP2 | 0.319 | − 0.200 | 0.70 | ||
| CXCL2 | 0.281 | − 0.223 | 0.71 | ||
| HBEGF | 0.346 | − 0.150 | 0.71 | ||
| LOC728835 | 0.322 | − 0.157 | 0.72 | ||
| CD83 | 0.283 | − 0.196 | 0.72 | ||
| LOC338758 | 0.208 | − 0.270 | 0.72 | ||
| IER2 | 0.313 | − 0.164 | 0.72 | ||
| CCL4L1 | 0.259 | − 0.210 | 0.72 | ||
| IER3 | 0.268 | − 0.195 | 0.73 | ||
| TNFAIP3 | 0.217 | − 0.244 | 0.73 | ||
| CCL20 | 0.369 | − 0.078 | 0.73 | ||
| LOC728830 | 0.355 | − 0.091 | 0.73 | ||
| NFKBIZ | 0.161 | − 0.278 | 0.74 | ||
| NFKBIA | 0.195 | − 0.227 | 0.75 | ||
| HES4 | 0.130 | − 0.277 | 0.75 | ||
| PPP1R15A | 0.316 | − 0.085 | 0.76 | ||
| G0S2 | 0.293 | − 0.103 | 0.76 | ||
| DDIT4 | 0.186 | − 0.184 | 0.77 | ||
| AXUD1 | 0.189 | − 0.181 | 0.77 | ||
| GADD45B | 0.187 | − 0.178 | 0.78 | ||
| CDKN1C | 0.141 | − 0.218 | 0.78 | ||
| CD69 | 0.111 | − 0.248 | 0.78 | ||
| TRIB1 | 0.182 | − 0.167 | 0.78 | ||
| BTG2 | 0.295 | − 0.048 | 0.79 | ||
| DUSP1 | 0.162 | − 0.174 | 0.79 | ||
| ADM | 0.225 | − 0.109 | 0.79 | ||
| HLA-DRB5 | 0.312 | − 0.010 | 0.80 | ||
| HLA-DRB1 | 0.220 | − 0.089 | 0.81 | ||
| ZFP36 | 0.218 | − 0.078 | 0.81 | ||
| FOS | 0.170 | − 0.121 | 0.82 | ||
| C5AR1 | 0.242 | − 0.049 | 0.82 | ||
| NFIL3 | 0.131 | − 0.156 | 0.82 | ||
| RPPH1 | 0.219 | − 0.067 | 0.82 | ||
| LOC643930 | 0.197 | − 0.081 | 0.82 | ||
| SNORA70 | 0.089 | − 0.185 | 0.83 | ||
| CCL4L2 | 0.279 | 0.006 | 0.83 | ||
| PNRC1 | 0.179 | − 0.094 | 0.83 | ||
| DEFA1 | 0.432 | 0.163 | 0.83 | ||
| PID1 | 0.212 | − 0.057 | 0.83 | ||
| NR4A2 | 0.140 | − 0.126 | 0.83 | ||