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. 2017 Oct 25;7:14049. doi: 10.1038/s41598-017-14417-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD8⁺ T cells are the main effector cells involved in combination therapy with anti-PD-1 and anti-CD4 mAb. All mice receiving a cell-depleting anti-CD8 mAb in association with combined anti-PD-1/anti-CD4 mAb therapy, after i.v. challenge with Neuro2a-luc (panel a) or NXS2-luc (panel b) cells, develop tumors in a similar fashion as mice receiving no therapy but only irrelevant mAb. P values of combined anti-PD-1/anti-CD4 mAb therapy + anti-CD8 mAb vs combined therapy are indicated (Wilcoxon log-rank test). Percentages of progression-free mice are indicated on the Y-axis and the fraction of progression-free mice of each group is given in brackets. The schedule shown in the inset shows the timing of treatments.