Table 4.

Comparison of PWB AD-DEGs with DEGs detected from various brain regions of AD patients.

Brain region	DEGs	Overlapped with AD-DEG	P-value*
Entorhinal Cortex	1334	5 (5)#	0.98
hippocampus	2346	26 (21)	1.90 × 10−2
Middle temporal gyrus	2253	28 (26)	2.52 × 10−3
Posterior cingulate cortex	3273	24 (24)	0.64
Superior frontal gyrus	5344	53 (49)	7.3 × 10−4
Primary visual cortex	373	9 (9)	1.91 × 10−3

^#The number outside the parentheses indicates the number of overlapped genes between AD-DEGs and brain tissue DEGs and the number inside the parentheses indicates the number of overlapped genes with consistent expression alterations in both PWB and brain tissue of AD patients. ^*Represent the probability of observing the number of overlapped genes by chance calculated by the hypergeometric distribution model.