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. 2017 Oct 25;7:14036. doi: 10.1038/s41598-017-14492-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathology of the kidneys in adenine-fed rats. (A) The average kidney weight in the control group was higher than that in the MSC group (P < 0.005). (B–E) Histopathological analysis of kidneys by haematoxylin–eosin staining and Masson-trichrome staining. Distention of tubular lumens (P < 0.01), interstitial fibrosis (P < 0.005), and reduction in glomerular numbers (P < 0.005) were observed in the control group as compared to those parameters in the MSC group. Data are expressed as the mean ± SEM. Black scale bars: 500 μm, white scale bars: 100 μm.