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. 2017 Oct 25;7:14036. doi: 10.1038/s41598-017-14492-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum parameters in adenine-fed rats. (A–G) Serum levels of blood urea nitrogen (BUN), creatinine (Cre), inorganic phosphorus (Pi), and calcium (Ca) in adenine-fed and control rats. (A,B) Mesenchymal stem cells (MSCs) transplantation significantly reduced serum BUN (P < 0.05) and Cr (P < 0.05) levels on day 42. (C,D,G) MSCs significantly reduced serum Pi (P < 0.05), FGF23 (P < 0.05), and intact parathyroid hormone (PTH) (P < 0.05) on day 56 as compared to those in the control group. (D,F). Serum levels of Ca and 1–25(OH)₂D₃ on day 56 did not significantly differ between the MSC and control groups. Data are expressed as the mean ± SEM.