Table 1.
Bone phenotype of 12-week-old C5aR1- and C5aR2-knockout mice.
| Parameters | WT | C5aR1−/− | C5aR2−/− | |
|---|---|---|---|---|
| Cortical bone | EI (Nmm2) | 2647 ± 241 | 4032 ± 657* | 3405 ± 800 |
| TMD (mg/cm3 of HA) | 1153 ± 27 | 1328 ± 16* | 1275 ± 23* | |
| Ix (mm4) | 0.15 ± 0.03 | 0.21 ± 0.03* | 0.16 ± 0.04 | |
| C.Th (mm) | 0.16 ± 0.02 | 0.20 ± 0.01* | 0.17 ± 0.01 | |
| Trabecular bone | BV/TV (%) | 24.3 ± 3.5 | 34.3 ± 2.6* | 30.6 ± 3.7* |
| TMD (mg/cm3 of HA) | 756 ± 41 | 806 ± 40 | 788 ± 31 | |
| Tb.N (1/mm) | 4.6 ± 0.2 | 5.1 ± 0.3* | 4.9 ± 0.4 | |
| Tb.Th (mm) | 0.05 ± 0.01 | 0.07 ± 0.01* | 0.06 ± 0.00* | |
| Tb.Sp (mm) | 0.17 ± 0.01 | 0.15 ± 0.01* | 0.16 ± 0.01* | |
| Ob.N/B.Pm (1/mm) | 13.6 ± 3.4 | 14.4 ± 2.5 | 16.3 ± 2.7* | |
| Oc.N/B.Pm (1/mm) | 2.3 ± 0.4 | 1.1 ± 0.2* | 2.3 ± 0.5 | |
| BFR/BS (µm3/µm2/t) | 0.4 ± 0.1 | 0.6 ± 0.1* | 0.3 ± 0.1 | |
| Serum | CTX (ng/mL) | 21.3 ± 9.8 | 25.5 ± 5.5 | 16.8 ± 2.7 |
| PINP (ng/mL) | 6.5 ± 1.8 | 10.0 ± 2.9* | 6.1 ± 1.4 |
N = 5, *p < 0.05 compared to WT mice. EI: bending stiffness, TMD: tissue mineral density, Ix: moment of inertia, C.Th: cortical thickness, BV/TV: bone volume per total volume, Tb.N: trabecular number, Tb.Th: trabecular thickness, Tb.Sp: trabecular separation, Ob.N/B.Pm: osteoblast number per bone perimeter, Oc.N/B.Pm: osteoclast number per bone perimeter, BFR/BS: bone formation rate per bone surface, CTX: C-terminal telopeptide, PINP: procollagen type I N-terminal propeptide.