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. 2017 Oct 25;7:14021. doi: 10.1038/s41598-017-14265-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of telmisartan-induced effects in the mice received hippocampal PPARδ knockdown. Normal mice and UCMS mice were transfected with scrambled shRNA or PPARδ shRNA, respectively. In the open field test, the animals were allowed to explore the open field arena for 5 min. (A) The total distance travelled; (B) the time spent in the central; (C) frequency of grooming; (D) frequency of rearing; (E) the percentage of sucrose solution consumed (%); (F) PPARδ expression levels in the hippocampus; (G) 5-HTT expression levels in the hippocampus. White columns indicated normal control goups, and black columns indecated UCMS goups. Data are presented as the mean ± SEM (n = 8 per group). *p < 0.05 and **p < 0.01 compared to the corresponding control; ^#p < 0.05 and ^##p < 0.01 compared to the UCMS group. Full-length blots are presented in Supplementary Fig. S3.