Figure 4.

Indices obtained from the zeroth persistence diagram PD₀ versus visual scoring of nuclear grade for positive cells (a–c) and negative cells (d–f). Box plots of (a) ${\mathrm{Center}}_{x1}$, (b) ${\mathrm{Center}}_{y1}$, and (c) WSS1 from the zeroth persistence diagrams PD₀ for positive cells versus pathologist-derived (visual scoring) nuclear grade (G1, G2 and G3 in horizontal axis), p < 0.0001(Kruskal-Wallis rank sum test) for ${\mathrm{Center}}_{x1}$ and ${\mathrm{Center}}_{y1}$, and p = 0.7003(Kruskal-Wallis rank sum test) for WSS1. Box plots of (d) ${\mathrm{Center}}_{x2}$, (e) ${\mathrm{Center}}_{y2}$, and (f) WSS2 from the zeroth persistence diagrams PD₀ for negative cells versus pathologist-derived (visual scoring) nuclear grade (G1, G2 and G3 in horizontal axis), p = 0.00064 (Kruskal-Wallis rank sum test) for ${\mathrm{Center}}_{x2}$, p = 0.01442(Kruskal-Wallis rank sum test) for ${\mathrm{Center}}_{y2}$, and p < 0.0001(Kruskal-Wallis rank sum test) for WSS2.