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. 2017 Oct 25;7:14000. doi: 10.1038/s41598-017-13912-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PINTA745 improves recovery of body weight following middle cerebral artery occlusion (MCAO). (A) Infarction in the right hemisphere (upper panel) and quantification of cerebral infarct volume (lower panel) 2 days after MCAO. (B) Infarction in the right hemisphere 14 days after MCAO (upper panel) and quantification of cerebral tissue loss. Cerebral tissue loss was expressed as the difference between contralateral and ipsilateral hemispheric volumes at day 14 after MCAO. Data are means ± SEM (n = 8–14/group). (C) Kinetic of body weight loss and recovery after cerebral ischemia. Data are means ± SEM (n = 7–12/group). Error bars not shown are within symbol size. **P < 0.01: vehicle-MCAO mice (MCAO) significantly different from Sham mice at the corresponding time point. ^††P < 0.01 and ^†††P < 0.001: MCAO mice significantly different from PINTA745-MCAO mice (MCAO + PINTA) at the corresponding time point.