Figure 2.
PINTA745 reduces skeletal muscle weight loss 15 days after middle cerebral artery occlusion (MCAO). (A) Weight of extensor digitorum longus, gastrocnemius, tibialis anterior and quadriceps muscles in Sham mice, vehicle-MCAO mice (MCAO) and PINTA745-MCAO mice (MCAO + PINTA). (B) Representative transverse sections of tibialis anterior muscle immunostained with anti-laminin antibody in Sham mice, MCAO mice and MCAO + PINTA mice. Images were acquired using a Leica TCS-SP2 confocal scanning laser inverted microscope (Leica-Microsystem, Heidelberg, Germany). Relative frequency distribution of fiber diameter and quantification of muscle fiber diameter in Sham, MCAO and MCAO + PINTA mice. Scale bar equals 100 µm. Data are means ± SEM (n = 5/group). *P < 0.05 and **P < 0.01.