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. 2017 Oct 25;7:14069. doi: 10.1038/s41598-017-13853-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagram of hippocampal cross-section showing putative regions involved in pattern separation (blue) and object recognition (orange) (a) and behavioural task of pattern separation (blue) and object recognition (orange) (b). Stimuli presented are similar (blue outline in b) and require pattern separation thought to occur in dentate gyrus granule cells and mossy fibre network (blue in a), identical (orange outline in b) requiring object recognition in CA3 neurons (orange neurons in a), rotated or new. Throughout the paper, data are presented for similar items as a measure of pattern separation, identical items as a measure of object recognition and rotated items as a measure of detection of coordinate remapping. However, data in the new item category were too clustered around perfect performance to obtain meaningful results and are therefore not analysed. Participants respond similar, identical rotated or new to each item presented on a computer screen. DG = Dentate gyrus, SUB = subiculum, EC = Entorhinal cortex, NC = Neocortex.