Table 1.

Anticancer and Wnt/β-catenin signaling data of tolfenamic amides 1a–1o

Cpd	Cell Line - CC50 (µM)			Wnt/β-catenin
	HT29	PC3	MDA-MB-231	% Control (100 µM)	% Control (10 µM)
1a	0.99 ± 0.35	5.89 ± 2.50	7.27 ± 6.61	4.78 ± 0.84	30.66 ± 2.88
1b	15.92 ± 2.14	25.37 ± 4.38	18.08 ± 4.64	13.23 ± 3.89	56.55 ± 3.55
1c	3.11 ± 0.49	9.43 ± 1.16	6.21 ± 3.20	8.40 ± 0.74	47.12 ± 4.65
1d	>50	>50	>50	51.15 ± 3.41	ND
1e	18.93 ± 1.29	26.42 ± 2.86	26.81 ± 1.98	66.61 ± 7.70	ND
1f	6.58 ± 0.58	7.92 ± 0.87	10.67 ± 0.85	N/A	148.21 ± 0.63
1g	8.74 ± 1.14	13.29 ± 1.56	16.57 ± 1.97	N/A	ND
1h	12.04 ± 1.24	35.05 ± 1.96	>50	69.26 ± 9.56	ND
1i	20.02 ± 1.83	>50	>50	157.05 ± 3.74	ND
1j	17.33 ± 1.64	>50	>50	81.87 ± 4.04	ND
1k	6.05 ± 0.58	14.51 ± 1.74	16.68 ± 1.82	N/A	128.71 ± 13.66
1l	7.15 ± 0.73	9.56 ± 0.83	10.39 ± 1.15	N/A	163.73 ± 7.58
1m	6.69 ± 0.43	8.19 ± 0.77	10.21 ± 0.93	N/A	179.39 ± 6.78
1n	11.31 ± 1.31	29.12 ± 3.22	21.11 ± 1.30	16.24 ± 2.39	129.82 ± 7.08
1o	5.43 ± 0.28	8.12 ± 0.89	14.15 ± 1.03	N/A	95.84 ± 0.30

N/A not available due to cell toxicity at this concentration, ND not done