Table 5.
Anticancer and Wnt/β-catenin signaling data of fenoprofen amides 5a–5o
| Cpd | Cell Line—CC50 (µM) | Wnt/β-catenin | |||
|---|---|---|---|---|---|
| HT29 | PC3 | MDA-MB-231 | % Control (100 µM) | % Control (10 µM) | |
| 5a | >50 | >50 | >50 | 9.60 ± 1.54 | 109.27 ± 12.08 |
| 5b | >50 | >50 | >50 | 6.77 ± 0.39 | 114.35 ± 18.16 |
| 5c | >50 | >50 | >50 | 71.24 ± 10.54 | ND |
| 5d | >50 | >50 | >50 | 4.76 ± 43 | 79.12 ± 6.12 |
| 5e | >50 | >50 | >50 | 82.57 ± 4.03 | ND |
| 5f | 29.6 ± 2.04 | >50 | >50 | 131.04 ± 5.43 | ND |
| 5g | 35.72 ± 9.18 | >50 | >50 | 139.50 ± 13.04 | ND |
| 5h | 15.07 ± 1.57 | >50 | >50 | 77.34 ± 5.76 | 116.65 ± 11.31 |
| 5i | 23.11 ± 3.60 | >50 | >50 | 114.07 ± 18.30 | ND |
| 5j | 17.57 ± 1.28 | 41.3 ± 3.34 | >50 | 140.26 ± 18.54 | ND |
| 5k | 7.46 ± 0.63 | 24.01 ± 3.84 | 30.8 ± 7.06 | 24.76 ± 4.86 | 131.90 ± 7.46 |
| 5l | 20.37 ± 1.82 | >50 | >50 | 125.69 ± 7.98 | ND |
| 5m | 28.51 ± 3.16 | >50 | >50 | 92.17 ± 8.49 | ND |
| 5n | 13.83 ± 1.30 | >50 | >50 | 101.52 ± 10.31 | ND |
| 5o | 7.9 ± 0.84 | 11.51 ± 0.90 | 13.22 ± 2.35 | 8.51 ± 1.30 | 82.33 ± 3.50 |
ND not done