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LNG released from IVRs suppressed normal cycling in macaques. Estradiol-17 (E, pg/dl) and progesterone (P, ng/ml) were measured in blood over time. Arrows indicate times IVRs were inserted/exchanged. The first SIV RNA positive time point for each animal is shown in red with red asterisks indicating that plasma virus RNA was only detected after challenges were concluded. Blue asterisks denote noticeable vaginal bleeding
