Fig. 5.

Residual drug levels in MZC and MZCL IVRs after removal. (a) The percentage of each drug remaining in the IVRs was determined by dividing drug content after removal by what was loaded. IVRs are shown individually from IVR-1 and IVR-5 cycles and both pore sizes from all macaques in each group. (b) The percentage of ZA and CG remaining in used IVRs by pore size and IVR cycle. Closed symbols represent IVR-1; open symbols represent IVR-5. (c) Spearman correlations between residual drug levels of the matrix (MIV-150 vs. LNG) and core (CG vs. ZA) components. (d) Correlations are shown between the total amounts of MIV-150, CG, and LNG detected in vivo and the amounts remaining in used IVRs post-removal