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Anti-SHIV-RT activity of MZC and MZCL IVRs in macaques following repeated co-challenge with SHIV-RT and HSV-2. (a) The percent of macaques remaining SHIV negative over time was calculated by measuring SIV RNA in plasma collected immediately before each challenge (n = 4 LNG, n = 12 MZCL, n = 4 placebo, n = 12 MZC). (b) Plasma viral loads and (c) antibody development were monitored over time
