Figure 4.

Effects of high salt on synaptic plasticity. Input/output (I/O) and long‐term potentiation (LTP) changes were measured in mice fed normal chow or a high salt diet. (A) I/O relationships after applying increasing stimulation to the stratum radiatum of the CA1 region in the hippocampus and recording the output. (B) LTP was induced at baseline intensity using high‐frequency stimulation. The amplitude of the field excitatory postsynaptic potential (fEPSP) was measured, and the results were normalized to the average value measured during the 20 min baseline period. (C) Recording continued for at least 90 min following high‐frequency stimulation (HFS), and the last 10 min was used to calculate the LTP and plot the histogram. Data are presented as mean ± SD, n ≥ 8 mice/group, ^* p < 0.05, ^*** p < 0.001.