Figure 2.

The TDM thresholds of selected KIs as percent of the mean/median exposure of the approved dose (blue bars). Overall, the thresholds were 81.7% of the mean exposure across all agents (orange bar), with a standard deviation of 17.4%. Dotted horizontal lines indicate 100% of mean exposure and 81% (the mean of the thresholds). This analysis suggests that across all kinase inhibitors, the target exposure matches with 81.7% of the population exposure and supports the view that targeting the population average could serve as a proxy, in the absence of a definitive TDM target.