Table 4.

Test Characteristics of Undetectable Concentrations of hsTnT at ED Arrival for AMI (N = All 7,130 Patients)

hsTnT Cutoff (ng/L)	Patients Ruled Out	Outcome	Events Below Cutoff	Sensitivity (95% CI)	NPV (95% CI)	LR– (95% CI)
<3	1,103 (15.4%;	7‐day AMI	0	100	100	0
	95% CI = 14.7%–16.3%)			(98.7–100)	(99.5–100)	(0–NA)
		30‐day AMI	0	100	100	0
				(98.7–100)	(99.5–100)	(0–NA)
		90‐day AMI	0	100	100	0
				(98.7 –100)	(99.5–100)	(0–NA)
<5	2,399 (33.6%;	7‐day AMI	1	99.8	99.9	0.007
	95% CI = 32.6%–34.8%)			(98.7–100)	(99.8–100)	(0.001–0.048)
		30‐day AMI	2	99.5	99.9	0.013
				(98.3–99.9)	(99.8–100)	(0.003–0.052)
		90‐day AMI	3	99.3	99.9	0.019
				(98.0–99.9)	(99.8–100)	(0.006–0.058)
<6	3,009 (42.2%;	7‐day AMI	1	99.8	99.9	0.005
	95% CI = 41.1%–43.4%)			(98.7–100)	(99.8–100)	(0.008–0.038)
		30‐day AMI	2	99.5	99.9	0.010
				(98.3–99.9)	(99.8–100)	(0.026–0.412)
		90‐day AMI	3	99.3	99.9	0.015
				(98.0–99.9)	(99.8–100)	(0.005–0.046)

AMI = acute myocardial infarction; hsTnT = high‐sensitivity cardiac troponin T; LR– = negative likelihood ratio; NPV = negative predictive value.