Table 3.
Comparison of Prestroke and Poststroke TQoL in Patients With Nonfatal Stroke
| Chlorthalidone | Amlodipine | Lisinopril | Total | |
|---|---|---|---|---|
| Total | ||||
| Total participants with stroke and TQoL | 250 | 149 | 160 | 559 |
| BL TQoL, mean (SD) | 0.84 (0.14) | 0.85 (0.13) | 0.86 (0.13) | 0.85 (0.14) |
| First poststroke TQoL, mean (SD) | 0.81 (0.17) | 0.78 (0.18) | 0.79 (0.19) | 0.79 (0.18) |
| Change in TQoL, mean (SD) | −0.04 (0.19) | −0.08 (0.19) | −0.07 (0.21) | −0.06 (0.19) |
| P value | 0.0011 | <0.0001 | 0.0001 | <0.0001 |
| Age 55–64 y | ||||
| Total participants with stroke and TQoL | 50 | 27 | 44 | 121 |
| BL TQoL, mean (SD) | 0.82 (0.16) | 0.81 (0.16) | 0.85 (0.14) | 0.83 (0.15) |
| First poststroke TQoL, mean (SD) | 0.81 (0.17) | 0.77 (0.19) | 0.80 (0.18) | 0.80 (0.18) |
| Change in TQoL, mean (SD) | −0.02 (0.22) | −0.04 (0.21) | −0.05 (0.22) | −0.04 (0.22) |
| P value | 0.5763 | 0.3103 | 0.1270 | 0.0754 |
| Age 65–74 y | ||||
| Total participants with stroke and TQoL | 116 | 74 | 75 | 265 |
| BL TQoL, mean (SD) | 0.84 (0.14) | 0.85 (0.14) | 0.85 (0.13) | 0.85 (0.14) |
| First poststroke TQoL, mean (SD) | 0.81 (0.18) | 0.77 (0.18) | 0.79 (0.18) | 0.80 (0.18) |
| Change in TQoL, mean (SD) | −0.04 (0.19) | −0.09 (0.20) | −0.07 (0.21) | −0.06 (0.20) |
| P value | 0.0411 | 0.0005 | 0.0079 | <0.0001 |
| Age 75+ y | ||||
| Total participants with stroke and TQoL | 84 | 48 | 41 | 173 |
| BL TQoL, mean (SD) | 0.86 (0.13) | 0.88 (0.11) | 0.88 (0.12) | 0.87 (0.12) |
| First poststroke TQoL, mean (SD) | 0.81 (0.17) | 0.80 (0.16) | 0.79 (0.21) | 0.80 (0.17) |
| Change in TQoL, mean (SD) | −0.05 (0.15) | −0.08 (0.16) | −0.09 (0.20) | −0.07 (0.17) |
| P value | 0.0015 | 0.0014 | 0.0089 | <0.0001 |
| Men | ||||
| Total participants with stroke and TQoL | 154 | 92 | 102 | 348 |
| BL TQoL, mean (SD) | 0.85 (0.15) | 0.85 (0.14) | 0.86 (0.14) | 0.85 (0.15) |
| First poststroke TQoL, mean (SD) | 0.82 (0.15) | 0.76 (0.18) | 0.78 (0.20) | 0.79 (0.18) |
| Change in TQoL, mean (SD) | −0.03 (0.17) | −0.09 (0.21) | −0.08 (0.23) | −0.06 (0.20) |
| P value | 0.0686 | 0.0001 | 0.0006 | <0.0001 |
| women | ||||
| Total participants with stroke and TQoL | 96 | 57 | 58 | 211 |
| BL TQoL, mean (SD) | 0.84 (0.13) | 0.86 (0.12) | 0.85 (0.12) | 0.85 (0.12) |
| First poststroke TQoL, mean (SD) | 0.78 (0.20) | 0.81 (0.16) | 0.81 (0.16) | 0.79 (0.18) |
| Change in TQoL, mean (SD) | −0.06 (0.20) | −0.05 (0.16) | −0.05 (0.17) | −0.05 (0.18) |
| P value | 0.0046 | 0.0145 | 0.0490 | <0.0001 |
| Blacks | ||||
| Total participants with stroke and TQoL | 95 | 51 | 68 | 214 |
| BL TQoL, mean (SD) | 0.84 (0.16) | 0.85 (0.14) | 0.86 (0.14) | 0.85 (0.15) |
| First poststroke TQoL, mean (SD) | 0.79 (0.19) | 0.81 (0.13) | 0.79 (0.19) | 0.80 (0.18) |
| Change in TQoL, mean (SD) | −0.05 (0.20) | −0.04 (0.17) | −0.07 (0.22) | −0.07 (0.23) |
| P value | 0.0162 | 0.0925 | 0.0085 | 0.0001 |
| Non-blacks | ||||
| Total participants with stroke and TQoL | 155 | 98 | 92 | 345 |
| BL TQoL, mean (SD) | 0.85 (0.13) | 0.86 (0.13) | 0.86 (0.12) | 0.85 (0.13) |
| First poststroke TQoL, mean (SD) | 0.81 (0.16) | 0.76 (0.19) | 0.79 (0.19) | 0.79 (0.18) |
| Change in TQoL, mean (SD) | −0.03 (0.18) | −0.09 (0.20) | −0.06 (0.20) | −0.06 (0.19) |
| P value | 0.0259 | <0.0001 | 0.0033 | <0.0001 |
BL indicates baseline; and TQoL, transformed quality of life.