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. Author manuscript; available in PMC: 2017 Oct 26.
Published in final edited form as: Eur J Neurosci. 2016 Oct 16;44(10):2829–2845. doi: 10.1111/ejn.13404

Table 1.

Composition of methyl-donor manipulated diets.

Dietary component Methyl-donor supplemented diet (SUP) Methyl-donor depleted diet (DEP)
Methionine (g) 7.50 0.60
Choline (g) 15.00 0.08
Folic Acid (mg) 15.00 0.20
Zinc (mg) 150.51 29.12
Vitamin B12 (mg) 0.01 0.01
Betaine (g) 15.00 0.00
Methionine (g) 7.50 0.60
Choline (g) 15.00 0.08
Folic Acid (mg) 15.00 0.20
Zinc (mg) 150.51 29.12

WKY rats were randomly assigned to either (1) a methyl donor supplemented (SUP) group receiving a diet enriched with higher than usual amounts of methyl donors and cofactors (folic acid, choline, methionine, and Vitamin B12; diet. No. A04062403, Research Diets Inc, New Brunkswick, NJ; termed methyl donor supplemented group (SUP); or (2) a methyl donor depleted (DEP) group fed chow that was 90% depleted of methyl donors (diet no. A04062402, Research Diets Inc, New Brunkswick, NJ).