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. 2016 Aug 15;34(29):3562–3569. doi: 10.1200/JCO.2016.68.1106

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© 2016 by American Society of Clinical Oncology

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Fig 2. — Average serum values of cytokines for all available patients in escalation cohorts (predose serum of days 1 and 29 analyzed). (A) AM0010 serum trough (C_min); (B) interleukin-18 (IL-18); (C) Spearman correlation between AM0010 C_min and IL-18 (R² = 0.5; P < .001); (D) latency-associated peptide (LAP) transforming growth factor beta (TGF-β); (E) average serum values of interferon-gamma (IFN-γ; left) and IL-4 (right) in patients in the dose-escalation cohorts treated at 20 to 40 μg/kg (predose serum analyzed on days 1 and 29). (*) P < .01. (†) P < .05. (‡) P < .001.