Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 5;98(4):821–834. doi: 10.1099/jgv.0.000728

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 The Authors

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

PMC Copyright notice

Fig. 5. — Drug-resistant viruses gain a replicative advantage when spreading by a cell-to-cell mechanism in the presence of cART. Cell-to-cell spread of drug-resistant viruses was compared to wild-type virus in the presence of a serial dilution of fixed-dosed PI- and RTI-based drug combinations. Infection was quantified by qPCR detection of HIV-1 pol DNA. HIV-1dm spreads more efficiently by a cell-to-cell mechanism compared to wild-type virus in the presence of LPV+TFV (a, b). HIV-1k103n spreads efficiently by a cell-to-cell mechanism compared to wild-type virus in the presence of TFV+EFV (c, d) and in the presence of TFV+EFV+3TC (e, f). A representative experiment of two independent repeats is shown. The error bars represent the standard deviation of the mean; UT, untreated.