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. 2017 May 5;98(4):821–834. doi: 10.1099/jgv.0.000728

Fig. 6.

Fig. 6.

M184V mutation restores susceptibility to AZT and cART during cell-to-cell spread of HIV-1. Cell-to-cell spread of NRTI mutant HIV-1m184V compared to cell-to-cell spread of HIV-1wt in the presence of RTI mono (a), dual (b) and triple therapy (c). (a) AZT effectively inhibits cell-to-cell spread of HIV-1m184v, although it is ineffective against cell-to-cell spread of HIV-1wt. (b) In the presence of a serial dilution of a fixed dose combination of AZT+3TC, cell-to-cell spread of HIV-1wt and HIV-1m184v are effectively blocked although HIV-1m184v has a replicative advantage over wild-type virus. (c) Triple combination of AZT+3TC+EFV potently inhibits cell-to-cell spread of both HIV-1wt and HIV-1m184v. The error bars represent the standard deviation of the mean and a representative from two independent experiments is shown. The bold lines represent the non-linear regression curve-fit and dotted lines represent actual data points.