Table 2. CI values against PI-resistant virus (HIV-1DM), RTI-resistant virus (HIV-1K103N) and wild-type virus during cell-cell spread.
| Virus | Combination index (CI)*† | Effect | ||||
|---|---|---|---|---|---|---|
| 50 | 75 | 90 | 95 | |||
| Combination (ratio=1 : 1000) | ||||||
| HIV-1wt | LPV+TFV | 0.03 (0.06) | 0.1 (0.01) | 0.12 (0.04) | 0.36 (0.2) | Synergistic |
| HIV-1dm | LPV+TFV | 0.14 (0.01) | 0.21 (0.01) | 0.29 (0.04) | 0.49 (0.1) | Synergistic |
| Combination TFV+EFV (ratio=1000 : 1) | ||||||
| HIV-1wt | TFV+EFV | 0.69 (0.05) | 0.46 (0.07) | 0.36 (0.05) | 0.35 (0.02) | Synergistic |
| HIV-1k103n | TFV+EFV | 1.1 (0.02) | 0.93 (0.01) | 0.82 (0.05) | 0.79 (0.1) | Synergistic/additive |
| Combination TFV+EFV+3TC (1000 : 10 : 1) | ||||||
| HIV-1wt | TFV+3TC+EFV | 0.08 (0.03) | 0.09 (0.01) | 0.12 (0.04) | 0.18 (0.01) | Synergistic |
| HIV-1k103n | TFV+3TC+EFV | 0.35 (0.02) | 0.39 (0.01) | 0.44 (0.02) | 0.48 (0.13) | Synergistic |
*Data are mean and standard sem from two independent experiments.
†50, 75, 90 and 95 indicate the percentage inhibition of infection in the presence of the combination being tested.